Oral Presentations OP02: Myelin and Diseases of Myelin
نویسندگان
چکیده
منابع مشابه
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin and found that myelin lamellae are broken down into vesicular structures at the innermost region of the myelin sheath. We demonstrated that mye...
متن کاملMyelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat.
The unlabeled peroxidase-antiperoxidase method has been used with antiserum against "myelin-associated glycoprotein" to establish the presence of the glycoprotein in myelin and myelin-forming cells of the developing rat nervous system. Myelin-associated glycoprotein is found in oligodendroglial cytoplasm before the beginning of myelination. Staining intensity of oligodendroglia increases during...
متن کاملSynthesis Myelin and Incorporation of Myelin Polypeptides into CNS
The distribution of newly synthesized proteolipid protein (PLP, 23 kdaltons) and myelin basic proteins (MBPs, 14-21.5 kdaltons) was determined in microsomal and myelin fractions prepared from the brainstems oi 10-30 d-old rats sacrificed at different times after an intracranial injection of 3~S-methionine. Labeled MBPs were found in the myelin fraction 2 min after the injection, whereas PLP app...
متن کاملSynthesis and incorporation of myelin polypeptides into CNS myelin
The distribution of newly synthesized proteolipid protein (PLP, 23 kdaltons) and myelin basic proteins (MBPs, 14-21.5 kdaltons) was determined in microsomal and myelin fractions prepared from the brainstems o1 10-30 d-old rats sacrificed at different times after an intracranial injection of 35S-methionine. Labeled MBPs were found in the myelin fraction 2 min after the injection, whereas PLP app...
متن کاملMyelin movement
alcium just got a promotion. Findings by Caroppo et al. (page 111) reveal that in addition to its many roles inside the cell, Ca 2 ϩ has a distinct extracellular purpose: it acts via a Ca 2 ϩ receptor (CaR) to regulate the function of gastric epithelial cells. It has been known for some time that extracellular Ca 2 ϩ can be sensed by the CaR. The team noted that a Ca 2 ϩ gradient was generated ...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2008
ISSN: 0022-3042,1471-4159
DOI: 10.1046/j.1471-4159.81.s1.45_1.x